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Charles River Japan and Germany, respectively) exhibits loss of DPP4 activity due to a G633R substitution near the DPP4 active site (145), which results in degradation of the immature DPP4 protein in the endoplasmic reticulum (146)

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Warfarin Administration of warfarin (25 mg) 35 minutes after repeated doses of BYETTA (5 mcg twice daily on days 1-2 and 10 mcg twice daily on days 3-9) in healthy volunteers delayed warfarin Tmax by approximately 2 hours