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In the stomach, stimulation of gastric δ-cells leads to somatostatin release, resulting in reduced gastric acid secretion and delayed gastric emptying (Figure 1A)

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Using two independent bioinformatic tools 29,30 , we found a significant overlap with transcripts associated with genetic susceptibility to obesity in humans, suggesting that GLP-1–MK-801 targets biological pathways implicated in common polygenic forms of human obesity 1,31 (Fig