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Thus, a number of studies have shown a positive association between plasma DPP-4 activity and BMI in non-diabetic individuals (78–80), and it has been proposed that the release of DPP-4 from adipose tissue may provide one explanation for the increased plasma DPP-4 activity measured in obese subjects
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As a result of these cellular processes, cognitive impairment and dementia can ensue with DM resulting in memory impairment and AD